I wonder if the common cold is something in the domain of humoral response. If it is that then IL-4 overexpression may cause the virus to be cleared earlier.
Also, AIDS is primarily a disease of a compromised cell-mediated response. What if the opposite of IL-4 overexpression is performed? Would it boost cell-mediate response, enhancing effectiveness of drugs?
I'm going too deep into unknown territory here.
http://www.jimmunol.org/cgi/content/full/jimmunol;163/8/4546
Although not related, this paper says something about IL-4 overexpression and prevention of cartilage destruction. The vector is a cold virus?
